SPOC, short for Statistical Processing of cryo-EM maps, is a software package which contains statistical tools for the analysis and processing of cryo-EM maps. Included are tools for Confidence Map generation, local map processing as well as resolution estimation (global and local) by permutation testing and false discovery rate control.
It can be accessed via GitHub
Beckers M., and Sachse C. (2020)
Permutation testing of Fourier shell correlation for resolution estimation of cryo-EM maps.
J Struct Biol 212, 107579