Statistical FSC resolution estimation of cryo-EM maps

FDR-FSC is a robust cryo-EM map resolution estimation tool that thresholds the Fourier Shell correlation curve by statistical permutation testing including false discovery rate control. The procedure accepts untreated half-maps and does not require any solvent-flattening masking.  


It was developed by the ER-C-3 institute and can be found here:

M. Beckers and C. Sachse,

‘Permutation testing of Fourier shell correlation for resolution estimation of cryo-EM maps’

Journal of Structural Biology, 212 (2020), 107579