The Ernst Ruska-Centre cryo-EM user facility is offering technical and scientific support to our academic and industrial users in EM methodologies. We provide access to the complete pipeline from sample preparation to image acquisition on state-of-the-art cryo-electron microscopes. Experienced users can operate the devices with minimal supervision and we will also teach and train new users to be independent. Some of the typical application cases are listed below. Reach out to us to learn more about our booking process and how we can assist you in your research endeavors.
Selected Publications
(A complete list of internal publications can be found here.)
Khorshid, S., Baumeister, J., De Lorenzi, F., Tiboni, M., Elsafy, S., Motta, A., Nucci, A., von Stillfried, S., Chatain, N., Kiessling, F., Koschmieder, S., Lammers, T., Casettari, L. & Sofias, A. M. Designing and modeling nanomedicines towards image-guided drug delivery in hematological malignancies. J. Control. Release 113932 (2025). https://doi.org/10.1016/j.jconrel.2025.113932
Mihyar, R., Shalmani, A. A., Wildt, V., Sheybanifard, M., Wang, A., May, J. N., Shahzad, S., Buhl, E. M., Rütten, S., Behrens, D., Walther, W., Tiboni, M., Casettari, L., Buyel, J. F., Rijcken, C. J. F., Hennink, W. E., von Stillfried, S., Kiessling, F., Shi, Y., Metselaar, J. M., … Peña, Q. Microfluidic formulation, cryoprotection and long-term stability of paclitaxel-loaded π electron-stabilized polymeric micelles. J Control Release. 2024;375:614-626. doi:10.1016/j.jconrel.2024.08.041
Schmidt, J. J., Brandenburg, V. B., Elders, H., Shahzad, S., Schäkermann, S., Fiedler, R., Knoke, L. R., Pfänder, Y., Dietze, P., Bille, H., Gärtner, B., Albin, L. J., Leichert, L. I., Bandow, J. E., Hofmann, E., & Narberhaus, F. Two redox-responsive LysR-type transcription factors control the oxidative stress response of Agrobacterium tumefaciens. Nucleic Acids Res. 2025;53(6):gkaf267. doi:10.1093/nar/gkaf267
Henderikx, R. J. M., Mann, D., Domanska, A., Dong, J., Shahzad, S., Lak, B., Filopoulou, A., Ludig, D., Grininger, M., Momoh, J., Laanto, E., Oksanen, H. M., Bisikalo, K., Williams, P. A., Butcher, S. J., Peters, P. J. & Beulen, B. W. A. M. M. VitroJet: new features and case studies Acta Cryst. D80 (2024). https://doi.org/10.1107/S2059798324001852
Henderikx, R. J. M., Schotman, M. J. G., Shahzad, S., Fromm, S. A., Mann, D., Hennies, J., Heidler, T. V., Ashtiani, D., Hagen, W. J. H., Jeurissen, R. J. M., Mattei, S., Peters, P. J., Sachse, C., & Beulen, B. W. A. M. M. Ice thickness control and measurement in the VitroJet for time-efficient single particle structure determination. J Struct Biol. 2024;216(4):108139. doi:10.1016/j.jsb.2024.108139
de Witt, J., Molitor, R., Gätgens, J., Ortmann de Percin Northumberland, C., Kruse, L., Polen, T. et al. Biodegradation of poly(ester-urethane) coatings by Halopseudomonas formosensis. Microbial Biotechnology, 17, e14362. (2024). https://doi.org/10.1111/1751-7915.14362
Bitzenhofer, N.L., Höfel, C., Thies, S., Weiler, A.J., Eberlein, C., Heipieper, H.J. et al. Exploring engineered vesiculation by Pseudomonas putida KT2440 for natural product biosynthesis. Microbial Biotechnology, 17, e14312. (2024). https://doi.org/10.1111/1751-7915.14312
Zielinski, M., Peralta Reyes, F.S., Gremer, L. et al. Cryo-EM of Aβ fibrils from mouse models find tg-APPArcSwe fibrils resemble those found in patients with sporadic Alzheimer’s disease. Nat Neurosci 26, 2073–2080 (2023). https://doi.org/10.1038/s41593-023-01484-4