Cryo-EM applications

The Ernst Ruska-Centre cryo-EM user facility is offering technical and scientific support to our academic and industrial users in EM methodologies. We provide access to the complete pipeline from sample preparation to image acquisition on state-of-the-art cryo-electron microscopes. Experienced users can operate the devices with minimal supervision and we will also teach and train new users to be independent. Some of the typical application cases are listed below. Reach out to us to learn more about our booking process and how we can assist you in your research endeavors.


1. Junglas B., Huber S.T., Heidler T., Schlösser R., Mann D., Hennig R., Clarke M., Hellmann N., Schneider D. and Sachse C. PspA adopts an ESCRT-III-like fold and remodels bacterial membranes. (2021) Cell online 23rd of June.

2. Huber S.T., Mostafavi S., Mortensen S.A., Sachse C. Structure and assembly of ESCRT-III helical Vps24 filaments. (2020) Sci Advances 6(34): eaba4897.

3. Jakobi A.J., Huber S.T., Mortensen S.A., Schultz S.W., Palara A., Kuhm T., Shrestha B.K., Lamark T., Hagen W.J.H., Wilmanns M., Johansen T., Brech A., and Sachse C. (2020) Structural basis of p62/SQSTM1 helical filaments and their role in cellular cargo uptake. Nat Commun 11(1):440.