{"id":4033,"date":"2021-05-14T22:19:15","date_gmt":"2021-05-14T22:19:15","guid":{"rendered":"https:\/\/er-c.org\/?page_id=4033"},"modified":"2025-01-15T11:06:52","modified_gmt":"2025-01-15T11:06:52","slug":"fdrthresholding","status":"publish","type":"page","link":"https:\/\/er-c.org\/index.php\/software\/cryo-em\/fdrthresholding\/","title":{"rendered":"FDRthresholding"},"content":{"rendered":"<div class=\"wp-block-image is-style-default ticss-e33f06d4\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"626\" height=\"240\" src=\"https:\/\/er-c.org\/wp-content\/uploads\/2021\/03\/Software.jpg\" alt=\"\" class=\"wp-image-1513\" style=\"width:1200px;height:190px\" srcset=\"https:\/\/er-c.org\/wp-content\/uploads\/2021\/03\/Software.jpg 626w, https:\/\/er-c.org\/wp-content\/uploads\/2021\/03\/Software-300x115.jpg 300w\" sizes=\"auto, (max-width: 626px) 100vw, 626px\" \/><\/figure>\n<\/div>\n\n<div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-headline so-widget-sow-headline-default-feea9c97c678\"\n\t\t\t\n\t\t><div class=\"sow-headline-container \">\n\t\t\t\t\t\t\t<h1 class=\"sow-headline\">\n\t\t\t\t\t\tFDRthresholding\t\t\t\t\t\t<\/h1>\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"decoration\">\n\t\t\t\t\t\t<div class=\"decoration-inside\"><\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t<h3 class=\"sow-sub-headline\">\n\t\t\t\t\t\tStatistical density thresholding of cryo-EM maps using &#8220;false discovery rate&#8221; control\t\t\t\t\t\t<\/h3>\n\t\t\t\t\t\t<\/div>\n<\/div>\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div id=\"wp-block-themeisle-blocks-advanced-columns-27948cc6\" class=\"wp-block-themeisle-blocks-advanced-columns has-1-columns has-desktop-equal-layout has-tablet-equal-layout has-mobile-equal-layout has-vertical-unset has-default-gap\"><div class=\"wp-block-themeisle-blocks-advanced-columns-overlay\"><\/div><div class=\"innerblocks-wrap\">\n<div id=\"wp-block-themeisle-blocks-advanced-column-cf76d8a1\" class=\"wp-block-themeisle-blocks-advanced-column\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:10%\"><\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:80%\">\n<p style=\"text-align: justify;\">Confidence maps are complementary maps generated from cryo-EM maps by means of statistical hypothesis testing and subsequent FDR control. They allow thresholding of EM maps based on the expected amount of background noise visible at the respective threshold and thus allow rigorous error assessment of visible features in the density.<\/p>\n<p style=\"text-align: justify;\">Additional post-processing like local filtering or local amplitude scaling (LocScale) can be incorporated in the framework in order to increase the statistical power.<\/p>\n<p style=\"text-align: left;\">More information can be found here:<\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-fill\"><a class=\"wp-block-button__link has-white-color has-text-color has-background wp-element-button\" href=\"https:\/\/git.embl.de\/mbeckers\/FDRthresholding\" style=\"background-color:#023d6b\" target=\"_blank\" rel=\"noreferrer noopener\">GitLab<\/a><\/div>\n<\/div>\n\n\n\n<div style=\"height:49px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div id=\"citationDataDisplay\" class=\"transparent\">\n<div id=\"citationText\" style=\"text-align: left;\" tabindex=\"0\">\n<div>\u00a0<\/div>\nBeckers, M., Jakobi, A. J. &amp; Sachse, C.: Thresholding of cryo-EM density maps by false discovery rate control (2019) IUCrJ 6, 18-33.<\/div>\n<\/div>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-fill\"><a class=\"wp-block-button__link has-white-color has-text-color has-background wp-element-button\" href=\"https:\/\/doi.org\/10.1107\/S2052252518014434\" style=\"background-color:#023d6b\" target=\"_blank\" rel=\"noreferrer noopener\">View Article<\/a><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:10%\"><\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":3887,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"class_list":["post-4033","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/er-c.org\/index.php\/wp-json\/wp\/v2\/pages\/4033","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/er-c.org\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/er-c.org\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/er-c.org\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/er-c.org\/index.php\/wp-json\/wp\/v2\/comments?post=4033"}],"version-history":[{"count":11,"href":"https:\/\/er-c.org\/index.php\/wp-json\/wp\/v2\/pages\/4033\/revisions"}],"predecessor-version":[{"id":9684,"href":"https:\/\/er-c.org\/index.php\/wp-json\/wp\/v2\/pages\/4033\/revisions\/9684"}],"up":[{"embeddable":true,"href":"https:\/\/er-c.org\/index.php\/wp-json\/wp\/v2\/pages\/3887"}],"wp:attachment":[{"href":"https:\/\/er-c.org\/index.php\/wp-json\/wp\/v2\/media?parent=4033"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}